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High physiologic concentration of E2 (200 pM) increases firing in GnRH neurons. A–C, Number of APs elevated 3 min after E2 administration evoked by the depolarizing current step. D, Changes in the resting potential showed no significant alteration. E, Rin presented no E2-dependent change during the 10 min period examined. F, Membrane capacitance also showed no change. G, Loose patch clamp recording also confirmed the elevation of firing rate; *p < 0.05.
