Figure 4.

Both GABAergic and glutamatergic inputs are detectable during proestrus afternoon. A, Picrotoxin decreased frequency of the mPSCs only partially. The residues were eliminated with the subsequent application of the ionotropic glutamate receptor blocker kynurenic acid. Average frequencies of the respective 5-5 min periods below the recording also showed this phenomenon. B, I-V curve shows that reversal potential of the glutamate mPSCs (5.23 mV) is near the calculated value of that of glutamate channel (6.66 mV). C, The AMPA/kainate-R inhibitor NBQX also abolished the residual mPSCs.