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. Author manuscript; available in PMC: 2019 Apr 11.
Published in final edited form as: Cell Host Microbe. 2018 Mar 29;23(4):549–556.e3. doi: 10.1016/j.chom.2018.03.001

Figure 1. I.n. RVG9R-siRNA elicits widespread gene silencing in the brain.

Figure 1.

(A) The indicated organs were examined for fluorescence 24 h after i.n. administration of PBS (mock), and 9R or RVG9R-complexed siFITC. Left- representative fluorescent images overlaid with their bright field images; Right- cumulative data from three mice depicting mean fluorescence intensities (MFIs) in arbitrary pixel values ± standard error (SE). (B) qPCR for SOD1 mRNA in mouse brain regions at 24 h after the last i.n. treatment with RVG9R-siSOD1 (solid bars) and RVG9R-siNT (open bars). Data are mean percent gene expression (± SD) relative to GAPDH after normalizing with corresponding data of mock-treated cohort. n = 3 mice per treatment per time point. NT-non-targeting. See also Figure S2.