Table 4.

Population-specific Paraclique: White Patients Diagnosed with Community-acquired pneumonia

GENE	FUNCTION
PDSS1; Decaprenyl-diphosphate synthase subunit 1	Supplies decaprenyl diphosphate, precursor for side chain of the isoprenoid quinones ubiquinone-10
EPAS1; endothelial PAS domain protein 1	Involved in induction of oxygen regulated genes. Binds to core DNA sequence within the hypoxia response element. Regulates VEGF expression and implicated in the development of blood vessels / tubular system of lung.
APOO; apolipoprotein O	Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. May be involved in myocardium-protective mechanisms against lipid accumulation
ALCAM; activated leukocyte cell adhesion molecule	Binds to CD6. Involved in neurite extension by neurons. May play a role in the binding of T- and B-cells to activated leukocytes
C9ORF30; chromosome 9 open reading frame 30
DLEC1; deleted in lung and esophageal cancer 1	May act as a tumor suppressor by inhibiting cell proliferation
HBEGF; heparin-binding EGF-like growth factor	Mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotion smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts.
OLFML2B; olfactomedin-like 2B
PER2; period homolog 2 (Drosophila)	Negative element in the circadian transcriptional loop.
SFMBT1; Scm-like with four mbt domains 1
THBS1; thrombospondin 1	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. Ligand for CD36 mediating antiangiogenic properties