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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Cancer Immunol Res. 2018 Jun 12;6(8):900–909. doi: 10.1158/2326-6066.CIR-17-0270

Figure 5. Histologic and immunophenotypic features of CTCL tumor, with 6-color multiplex immunohistochemistry for immune checkpoint expression.

Figure 5

Multiplex images performed on skin sections of MF lesion from a representative patient with tumor lesion (T3) is shown. PD-1 co-localizes with CD3, CD4, and CD8 expression. PD-1 and PD-L1 expression do not overlap. Higher expression of PD-1 and PD-L1 expression is noted on tumor lesion (T3), compared with plaque (T2, Fig. 4). [200x magnification; insets represent 400x magnification of small regions of multiplex images]. Representative data from 3 independent experiments are shown.