Table 2.
Genotype and allele frequencies of the TNF-α −308 G/A and IL-6 −174 G/C polymorphism in the study population.
| TNF-α −308 G/A |
Controls n (%) 300 (100) |
Patients n (%) 250 (100) |
OR | 95% CI | P value |
|---|---|---|---|---|---|
|
| |||||
| GG | 223 (74) | 72 (29) | 7.16 | 4.91–10.44 | <.0001 |
| GA+AA | 77 (26) | 178 (71) | |||
| G | 510 (85) | 293 (59) | 4.00 | 3.00–5.33 | <.0001 |
| A | 90 (15) | 207 (41) | |||
| IL-6 –174 G/C | |||||
| GG | 252 (84) | 182 (73) | 1.96 | 1.29–2.97 | .0019 |
| GC+CC | 48 (16) | 68 (27) | |||
| G | 544 (91) | 419 (84) | 1.87 | 1.30–2.70 | .0008 |
| C | 56 (9) | 81 (16) | |||
Notes: P value calculated by chi-square test. A P value <.05 indicates statistical significance.
Abbreviations: TNF-α: Tumor necrosis factor-alpha; IL-6: interleukin-6; n: number; OR: odds ratio; CI: confidence interval.