Table 3.
Haplotype analysis of the TNF-α −308 G/A and IL-6 −174 G/C polymorphism in IDCM patients and control subjects.
| TNF-α −308/IL-6 −174 |
Controls n (%) 300 (100%) |
Patients n (%) 250 (100%) |
χ2 | 95% CI | P value |
|---|---|---|---|---|---|
|
| |||||
| G-G | 461 (77) | 263 (53) | Reference | ||
| G-C | 49 (8) | 30 (6) | 0.02 | 1.07 (0.66–1.7) | .868 |
| A-G | 83 (14) | 156 (31) | 60.8 | 3.29 (2.4–4.5) | <.0001 |
| A-C | 7 (1) | 51 (10) | 57.3 | 12.8 (5.7–28.5) | <.0001 |
Notes: P value calculated by chi-square test (Yates corrected). A P value <.05 indicates statistical significance.
Abbreviations: TNF-α: Tumor necrosis factor-alpha; IL-6: interleukin-6; IDCM: idiopathic dilated cardiomyopathy; n: number; CI: confidence interval.