Table 2.
Allele frequencies in schizophrenic patients and controls.
| HLA | Schizophrenic patients (2N=280) n (%) |
Controls (2N= 200) n (%) |
OR (95% CI) | P |
|---|---|---|---|---|
|
| ||||
| aHLA-DRB1 | ||||
| DRB1* 04 | 48.0 (17.1) | 27.0 (13.5) | 1.3 (0.8–2.3) | .27 |
| DRB1*11 | 56.0 (20.0) | 28.0 (14.0) | 1.5 (0.9–2.6) | .56 * |
| DRB1*03 (s) | 94.0 (33.6) | 23.0 (11.5) | 3.9 (2.3–6.7) | <10−3 * |
| DRB1*15 | 18.0 (6.4) | 13.0 (6.5) | 1.0 (0.4–2.2) | .97 |
| DRB1*01 | 16.0 (5.7) | 17.0 (8.5) | 0.6 (0.3–1.4) | .23 |
| DRB1*13 (p) | 16.0 (5.7) | 28.0 (14.0) | 0.4 (0.2–0.7) | .013* |
| DRB1*07 | 32.0 (11.4) | 36.0 (18.0) | 0.6 (0.3–1.0) | .28* |
| bHLA-DQB1 | ||||
| DQB1*02 (s) | 126.0 (45.0) | 49.0 (24.5) | 2.5 (1.7–3.8) | <10−3* |
| DQB1*03 | 104.0 (37.1) | 69.0 (34.5) | 1.1 (0.8–1.7) | .55 |
| DQB1*06 | 34.0 (12.1) | 25.0 (12.5) | 1.0 (0.5–1.8) | .90 |
| DQB1*05 (p) | 16.0 (5.7) | 43.0 (21.5) | 0.2 (0.1–0.4) | <10−3 * |
CI: Confidence interval; OR: odds ratio; P: probability value.
*
denotes Bonferroni-corrected P value; significant P value is in bold, P<.05. (s), confers susceptibility; (p), confers protection; OR detected with at least 80% power is in bold.