Table 3.
The frequencies of HLA DR/DQ haplotypes in schizophrenic patients and controls.
| HLA-DRB1/DQB1 | Schizophrenic patients (2N=280) n (%) |
Controls (2N=200) n (%) |
OR (95% CI) | P |
|---|---|---|---|---|
|
| ||||
| DRB1*03/DQB1*02 (s) | 94.0 (33.6) | 17.0 (8.5) | 5.4 (3.1–10.1) | <10−3* |
| DRB1*04/DQB1*03 (s) | 48.0 (17.1) | 16.0 (8.0) | 2.4 (1.3–4.6) | .021* |
| DRB1*11/DQB1*03 (s) | 56.0 (20.0) | 16.0 (8.0) | 2.9 (1.6–5.5) | .0014* |
| DRB1*15/DQB1*06 | 18.0 (6.4) | 13.0 (6.5) | 1.0 (0.4–2.2) | .97 |
| DRB1*13/DQB1*06 | 16.0 (5.7) | 12.0 (6.1) | 0.9 (0.4–2.2) | .89 |
| DRB1*01/DQB1*05 | 16.0 (5.7) | 17.0 (8.5) | 0.6 (0. 3–1.4) | .23 |
| DRB1*07/DQB1*02 | 32.0 (11.4) | 29.0 (14.5) | 0.8 (0.4–1.4) | .31 |
CI: Confidence interval; OR: odds ratio; P value: probability value.
*
denotes Bonferroni-corrected P value; significant P value is in bold, P<.05. (s), confers susceptibility; OR detected with at least 80% power is in bold.