Table 1.
Human monogenic Nephrotic Syndrome (NS) genes and their Drosophila orthologs
| Human Gene | Drosophila Ortholog | Function | Cellular Localization | Renal Pathology |
|---|---|---|---|---|
| NPHS1 | Sns | Filtration | SD | SRNS |
| NPHS2 | Mec2 | Linker | SRNS | |
| CD2AP | Cindr | Adaptor protein | SRNS | |
| PTPRO | Ptp10D | Receptor-type tyrosine phosphatase | SRNS | |
| TRPC6 | Trpgamma | Calcium channel | SRNS | |
| MYH9 | Zip | Myosin motor | Actin Cytoskeleton | SRNS |
| MYO1E | Myo61F | SRNS | ||
| ACTN4 | Actn | Actin binding | SRNS | |
| INF2 | Form3 | SRNS | ||
| SYNPO | CG1674 | NS | ||
| ANLN | Scra | SRNS | ||
| KANK1 | Kank | Actin regulation | SRNS | |
| KANK2 | SRNS | |||
| KANK4 | SRNS | |||
| ARHGAP24 | RhoGAP92B | Signaling | SRNS | |
| ARHGDIA | RhoGDI | SRNS | ||
| LMX1B | CG32105 | Transcription factor | Nucleus | SRNS |
| SMARCAL1 | Marcal1 | SRNS | ||
| PAX2 | Sv | NS | ||
| E2F3 | E2f | NS | ||
| NXF5 | Sbr | RNA export | NS | |
| ZMPSTE24 | Ste24a | Lamin A processing | NS | |
| LMNA | Lam | Lamina | NS | |
| CUBN | Cubn | Endocytosis | Plasma membrane | IGS |
| AMN | Amn | IGS | ||
| SCARB2 | Emp | Proteolysis | Lysosome | SRNS |
| PMM2 | CG10688 | Glycosylation | Cytosol | NS |
| ALG1 | CG18012 | ER | NS | |
| COQ2 | Coq2 | Coenzyme Q synthesis | Mitochondrion | SRNS |
| COQ6 | CG7277 | SRNS | ||
| PDSS2 | CG10585 | SRNS | ||
| ADCK4 | CG32649 | SRNS | ||
| GPC5 | Dally | Signaling | Plasma membrane | NS |
| ITGA3 | Mew | Adhesion | SRNS | |
| ITGB4 | Mys | SRNS | ||
| CD151 | Tsp74F | NS | ||
| LAMB2 | LanB1 | GBM Structure | ECM | SRNS |
| COL4A3 | Col4a1 | Alport | ||
| COL4A4 | Alport | |||
| COL4A5 | Alport |