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Effect of DOX exposure on oocyte maturation in vivo. A, MII percentage of oocytes from mice treated with DOX at 0, 0.4, 2, and 10 mg/kg. B, Incidence of spindle abnormality and chromosome misalignment of MII oocytes from mice treated with DOX at 0, 0.4, 2, and 10 mg/kg. *P < 0.05, **P < 0.01, and ***P < 0.001; NS: nonsignificant; error bar: standard deviation. N = 4–6 mice and 20–30 oocytes per mice in each DOX-treated dosage.
