| Is there a strong association between OCT measures and MS-related disease activity, or the effect of treatment on both? |
| Do associations between OCT measures and MS disease activity persist across different sites, for different patient populations? |
| Is the OCT finding (ie, microcystic macular edema) associated specifically with MS? |
| Do OCT measures change in parallel with changes in MS disease activity and/or course? |
| Do credible mechanisms connect OCT measures, the pathogenesis of MS, and the mode of action of MS therapies? |
Note: Data adapted from Aronson.19
Abbreviations: OCT, optical coherence tomography; MS, multiple sclerosis.