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MiR-378 directly inhibited the expression of CDK1 through targeting its 3′UTR.
Notes: (A and B) A target miRNA prediction website and Dual-Luciferase Reporter assay showed the binding site between miR-378 and CDK1. Data are expressed as mean ± SD, n=3, *P<0.05. (C and D) Upregulated expression of miR-378 reduced both the CDK1 mRNA and protein levels. Data are expressed as mean ± SD, n=3, *P<0.05.
Abbreviations: NC, negative control; MUT, mutant; WT, wild-type.
