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. 2017 Jun 20;26(18):3495–3507. doi: 10.1093/hmg/ddx235

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Published by Oxford University Press 2017. This work is written by US Government employees and is in the public domain in the US.

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Wnt/β−catenin pathway analysis in Armc5^+/− adrenals. (A) Immunohistochemical analysis of β-catenin shows a normal expression in the zona glomerulosa (ZG) of Armc5^+/− adrenals. However, the ZG is invaded by the fibroblastic like cells (arrows) that did not express β-catenin. (B) The β-catenin target genes Axin2, Lef1 and CyclinD1 are significantly increased in Armc5^+/− adrenals at 18 months old. Their expression was analyzed by RTqPCR on mRNA from 12 and 18-month-old Armc5^+/+ and Armc5^+/− adrenals. Bars represent the induction fold of at least six individual adrenals ± standard deviation. P-value was calculated using Student’s t-test.