Table 4.

Results for which regional brain volumes are smaller for HIV+ individuals with DNP compared to HIV+ individuals without DNP and HIV+ individuals with larger DNP ratings. As described in Table 1, statistical models #1 and #2 investigate regional brain volumes smaller for HIV+ individuals with DNP compared to HIV+ individuals without DNP, while statistical models #3 and #4 investigate regional brain volumes which are smaller for HIV+ individuals with larger DNP ratings

Statistical model	Brain region	P value (peak)	T score	MNI coordinates	Cluster volume # voxels P values < 0.05
#1 Unadjusted analysis of brain regions smaller for DNP compared to no DNP	Left ventral PCC	0.034	4.71	X = −6, Y = −52, Z = 18	43
#2 Adjusted analysis of brain regions smaller for DNP compared to no DNP	Left ventral PCC	0.017	5.15	X = −6, Y = −54, Z = 20	65
#3 Unadjusted analysis of brain regions smaller for HIV+ individuals with larger DNP ratings	Left ventral PCC	0.058 (Trend)	3.83	X = −6, Y = −54, Z = 20	0
	R PCG	0.012	4.41	X = 32, Y = −22, Z = 46	174
	R caudate	0.050	2.80	X = 16, Y = 40, Z = 40	18
	R putamen	0.042	3.00	X = 26, Y = 10, Z = 6	91
	L putamen	0.045	3.00	X = −24, Y = 6, Z = 6	84
	R insula cortex	0.038	3.71	X = 30, Y = 28, Z = 4	82
	L insula cortex	0.049	3.00	X = -28, Y = 22, Z = 10	42
	L OFC	0.043	3.93	X = −48, Y = 30, Z = −12	17
#4 Adjusted analysis of brain regions smaller for HIV+ individuals with larger DNP ratings	Left ventral PCC	0.049	4.22	X = −6, Y = −54, Z = 20	3

DNP = distal neuropathic pain; PCC = posterior cingulate cortex; PCG = precentral gyrus cortex; OFC = orbital frontal cortex.