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. 2017 Jun 30;26(R2):R225–R236. doi: 10.1093/hmg/ddx253

Table 1.

Loci protective against malaria that are associated with inherited diseases

Gene Cost References
HBA α thalassemia (134)
HBB β thalassemia (134)
HBB sickle cell (135,136)
G6PD favism, hemolysis, jaundice (137-139)
CD36 impaired fatty acid metabolism, glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer disease (140,141)
ACKR1 benign ethnic neutropenia (142-145)
HBG1 hyperuricemia, hypertension (146,147)
GYPA/GYPB/GYPE ovalocytosis, anemia (148)