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. 2018 Aug 1;32(15-16):1060–1074. doi: 10.1101/gad.316034.118

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© 2018 Lee et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — A large number of hnRNPA1 and DDX5 splicing targets are coregulated. (A) JUM and MISO analysis independently identified significant overlap between the splicing targets of hnRNPA1 and DDX5. Approximately 66% of hnRNPA1 and 40% DDX5 splicing targets are shared between hnRNPA1 and DDX5. (B) eCLIP analysis confirms that the binding targets are shared between hnRNPA1 and DDX5. (C) Genome browser shot of the ZNF692 gene region with RNA-seq data upon hnRNPA1 knockdown (top) and DDX5 knockdown (bottom), with corresponding nuclear CLIP peak cluster regions shown below. The shared hnRNPA1/DDX5-binding site is highlighted on the genome browser.