TABLE 2.
Associations (Marginal) Between APEX1 and OGG1 SNP Genotypes and PD in PEG Participants
| Variant/Genotype | Patients |
Controls |
Adjusted ORa |
P-Value |
|---|---|---|---|---|
| Genotype n (%) | (95% CI) | |||
| APEX1 rs1130409 | ||||
| TT | 200 (33) | 276 (33) | 1.00 (ref) | – |
| GT | 284 (47) | 400 (47) | 0.98 (0.76, 1.26) | .88 |
| GG | 126 (21) | 172 (20) | 1.01 (0.74, 1.36) | .97 |
| TT/GT vs GG (ref) | 0.98 (0.76, 1.28) | .91 | ||
| OGG1 rs1052133 | ||||
| CC | 352 (58) | 480 (56) | 1.00 (ref) | – |
| CG | 221 (36) | 306 (36) | 1.01 (0.81, 1.27) | .90 |
| GG | 39 (6) | 67 (8) | 0.80 (0.52, 1.23) | .31 |
| CG/GG vs CC (ref) | 0.98 (0.78, 1.21) | .83 | ||
| Combined genetic risk score | ||||
| APEX1 GG and/or OGG1 CC | 405 (66) | 559 (65) | 1.00 (ref) | – |
| APEX1 TT or TG and OGG1 CG or GG | 208 (34) | 295 (35) | 1.01 (0.80, 1.26) | .96 |
a
Adjusted for age, sex, ever smoked, and European ancestry.