TABLE 3.
Associations Between Ambient Pesticide Exposures at Residences and Work Places Grouped by Presumed Function and PD in PEG Participants
| Pesticide | CA-DPR Chem Code | Cases (n = 545) | Controls (n = 854) | Adjusted ORa(95% CI) | P-Value |
|---|---|---|---|---|---|
| Mitochondrial complex I inhibitors | |||||
| Thiabendazole | 587 | 0 | 0 | – | |
| Carbendazim | 2176 | 0 | 0 | – | |
| Rotenone | 518 | 6 | 12 | 0.76 (0.28, 2.06) | .58 |
| Cyhalothrin | 2297 | 7 | 10 | 1.18 (0.44, 3.18) | .74 |
| Benomyl | 1552 | 177 | 207 | 1.51 (1.18, 1.93) | .0009 |
| Permethrin | 2008 | 82 | 82 | 1.70 (1.21, 2.37) | .002 |
| (S)-cypermethrin | 3866 | 5 | 6 | 1.64 (0.49, 5.51) | .43 |
| Cypermethrin | 2171 | 24 | 22 | 2.00 (1.09, 3.67) | .03 |
| Pyridaben | 3959 | 14 | 14 | 1.70 (0.79, 3.68) | .18 |
| Mitochondrial inhibitor combined | None/Low (0–2) | 437 | 749 | ref | – |
| High (>2) | 108 | 103 | 1.79 (1.32, 2.42) | .0002 | |
| Oxidative stressors | |||||
| Carbon disulfide | 108 | 1 | 2 | – | |
| Dichlone | 202 | 3 | 4 | – | |
| Mercury compounds | 454 | 0 | 0 | – | |
| Pybuthrin | 486 | 15 | 34 | 0.68 (0.36, 1.27) | .22 |
| Cyhalothrin | 2297 | 7 | 10 | 1.18 (0.44, 3.18) | .74 |
| Paraquat | 1601 | 245 | 296 | 1.54 (1.23-1.93) | .0002 |
| Permethrin | 2008 | 82 | 82 | 1.70 (1.21, 2.37) | .002 |
| (S)-cypermethrin | 3866 | 5 | 6 | 1.64 (0.49, 5.51) | .43 |
| Cypermethrin | 2171 | 24 | 22 | 2.00 (1.09, 3.67) | .03 |
| Oxidative stressor combined | None/Low (0–2) | 409 | 703 | ref | – |
| High (>2) | 136 | 149 | 1.61 (1.22, 2.11) | .0007 |
Chloranil considered an oxidative stressor, was not recorded in the CADPR.
a
Adjusted for age, sex, ever-smoked, and European ancestry; reference for each individual chemical is the chemical specific unexposed groups (not shown).