Table 2.
Associations between log of CRP levels and trajectories of functional status
| Variable | Change in BI score | 95% CI | P-value |
|---|---|---|---|
| Unadjusted model | |||
| Annual change in BI score | −1.01 | −1.09, −0.93 | <0.0001 |
| Change in BI score per unit increase in log of CRP levels | −0.72 | −1.13, −0.31 | 0.0006 |
| Additional annual change in BI score per unit increase in log of CRP levels | −0.03 | −0.10, 0.05 | 0.5 |
| Adjusted for demographicsa | |||
| Annual change in BI score | −1.02 | −1.10, −0.94 | <0.0001 |
| Change in BI score per unit increase in log of CRP levels | −0.79 | −1.22, −0.36 | 0.0003 |
| Additional annual change in BI score per unit increase in log of CRP levels | −0.03 | −0.10, 0.04 | 0.4 |
| Adjusted for vascular risk factorsb | |||
| Annual change in BI score | −1.03 | −1.11, −0.94 | <0.0001 |
| Change in BI score per unit increase in log of CRP levels | −0.40 | −0.85, 0.05 | 0.08 |
| Additional annual change in BI score per unit increase in log of CRP levels | −0.03 | −0.11, 0.04 | 0.4 |
| Adjusted for social variablesc | |||
| Annual change in BI score | −1.01 | −1.09, −0.93 | <0.0001 |
| Change in BI score per unit increase in log of CRP levels | −0.33 | −0.78, 0.11 | 0.14 |
| Additional annual change in BI score per unit increase in log of CRP levels | −0.03 | −0.11, 0.04 | 0.4 |
| Adjusted for mood and cognitive variablesd | |||
| Annual change in BI score | −0.57 | −0.72, −0.43 | <0.0001 |
| Change in BI score per unit increase in log of CRP levels | −0.30 | −0.58, −0.02 | 0.04 |
| Additional annual change in BI score per unit increase in log of CRP levels | 0.00 | −0.12, 0.13 | 0.96 |
| Adjusted for stroke and MIe | |||
| Annual change in BI score | −0.39 | −0.53, −0.26 | <0.0001 |
| Change in BI score per unit increase in log of CRP levels | −0.34 | −0.62, −0.06 | 0.02 |
| Additional annual change in BI score per unit increase in log of CRP levels | 0.02 | −0.11, 0.14 | 0.8 |
aAdjusted for: baseline age, sex and race-ethnicity.
bAdditionally adjusted for: diabetes, hypertension, coronary artery disease, hypercholesterolaemia, physical activity, alcohol use, smoking and body mass index.
cAdditionally adjusted for: marital status, insurance, number of friends and years lived in the neighbourhood.
dAdditionally adjusted for: depression, mini-mental state score and Spitzer quality of life index.
eAdditionally adjusted for: stroke or myocardial infarction occurring during follow-up.