Table 2.
iDriver novel driver genes validation results
| Analysis | BRCA | CRC | GBM | OV | |
|---|---|---|---|---|---|
| Gene sets distances | Distance | 5 | 4 | 5 | 5 |
| p value | 0.002 | 0.001 | 0.001 | 0.009 | |
| Connectivity analysis | Degree | 5.5 | 5.5 | 5 | 3 |
| p value | 0.004 | 0.003 | 0.003 | 0.023 | |
| Purifying selection analysis | Count | 6 | 4 | 4 | 4 |
| p value | 0.003 | 0.015 | 0.015 | 0.015 | |
| Pathway analysis | Cancer pathwaysa | 1 | 2 | 5 | 3 |
| Expression analysis | p value | 1.1 × 10−5 | 0.020 | 0.046 | 7.3 × 10−5 |
| ShRNA screen analysis | Count | 6 | 3 | 3 | 3 |
| p value | 9.0 × 10−5 | 0.042 | 0.042 | 0.042 |
a
Number of enriched KEGG cancer related pathways. Detail is in Supplementary Table 8.