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. 2016 Sep 29;72(6):771–779. doi: 10.1093/gerona/glw175

Figure 5.

Figure 5.

The number and size of intrafusal muscle fibers (IMFs) are unchanged in older mice. Nuclear bag fibers were stained using an antibody against S46, which binds to slow-tonic myosin heavy chain isoform (A–C). The perimeter of all muscle fibers was labeled with an antibody against laminin (A–C). We examined the tibialis anterior muscle of 2-month (A), 11-month (B), and 17-month-old (C) animals. The number of IMFs per spindle is similar between young and older mice (D). Aging did not affect the size of S46-positive and S46-negative IMFs (E). S46-positive IMFs do not differ between mice of different age groups (F). At least three animals per age group and at least 30 muscle fibers per muscle were analyzed. Scale bar = 50 µm. Error bar = STE. *p < .05, **p < .01, ***p < .001.