Table 1.

New associations with lipid traits identified in the East Asian meta-analysis (P < 5 × 10⁻⁸)

Trait	Variant	Chr	Position	Locus	N	EA/NEA	EAF	Adjusted for age, sex				Adjusted for age, sex, BMI
								Beta	SE	P-value	Phet	Beta	SE	P-value	Phet
TG	rs10886863	10	122,929,493	WDR11-FGFR2	45,245	C/T	0.64	0.041	0.007	2.71 × 10−8	0.275	0.041	0.006	2.73 × 10−10	0.175
HDL-C	rs10743940	12	7,651,138	CD163-APOBEC1	34,243	A/T	0.30	0.050	0.009	7.00 × 10−9	0.105	0.050	0.008	2.30 × 10−9	0.163
HDL-C	rs10504476	8	71,267,629	NCOA2	42,731	G/A	0.60	0.040	0.007	2.11 × 10−7	0.993	0.042	0.007	1.62 × 10−8	0.812
HDL-C	rs10144765	14	52,559,930	NID2-PTDGR	54,176	G/C	0.27	0.031	0.007	1.63 × 10−6	0.626	0.035	0.007	4.16 × 10−8	0.380

East Asian meta-analysis results from Phases 1 and 2 (without and with adjustment for BMI). Genome-wide significant association is defined as P < 5 × 10⁻⁸. Physical positions based on hg19. Effect alleles are associated with higher triglyceride and HDL-C trait values. Beta estimates reflect per allele effects of variants on inverse normal transformed traits. rs10743940 at CD163-APOBEC1 attained genome-wide significance at Phase 2 (N up to 34,421). The other three loci attained genome-wide significance from combined analysis of Phase 1 discovery, in silico, and de novo stages (N up to 61,607 for HDL-C, and N up to 45,839 for TG).

Chr, chromosome; EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; SE, standard error; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol.