Figure 2.

Effects of eszopiclone on the latency to sleep onset in undisturbed mice and in mice that were subjected to 6-hour sleep deprivation. Eszopiclone, sleep deprivation, or combination of eszopiclone and sleep deprivation significantly reduced the latency to sleep onset. Data represent the mean ± SEM percentage of wake, REM sleep, and NREM sleep from the total recording time. Statistical comparisons were made among all groups; letters at the top of bars indicate significant differences (p < .05) compared to the treatment groups indicated (from left to right: a–d). NREM = nonrapid eye movement; REM = rapid eye movement; RS = recovery sleep after sleep deprivation; SEM = standard error of the mean.