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. 2017 Jun 12;40(7):zsx098. doi: 10.1093/sleep/zsx098

Figure 3.

Figure 3

Effects of eszopiclone on wakefulness, REM sleep, and NREM sleep in undisturbed mice and in mice that were subjected to 6-hour sleep deprivation. Eszopiclone (20 mg/kg) or saline was injected ip at ZT6, and sleep was recorded 160 minutes following the injection. Saline-treated animals had significantly higher amounts of wakefulness than eszopiclone-treated mice or mice recorded during the recovery sleep period (RS) after sleep deprivation. Data represent the mean ± SEM percentage of wake, REM sleep, and NREM sleep from the total recording time. Statistical comparisons were made among all groups; letters at the top of bars indicate significant differences (p < .05) compared to the treatment groups indicated (from left to right: a–d). NREM = nonrapid eye movement; REM = rapid eye movement; RS = recovery sleep after sleep deprivation; SEM = standard error of the mean.