FIG. 4.

Hepatic transferase activities (phase II enzyme activities) for wild-type and Lrat^−/− mice after bisphenol A administration. UDP-glucuronosyl transferase (Panel A) activity was determined for microsomes isolated from livers of mice 72 h after per os administration of corn oil (vehicle) or bisphenol A (BPA, at a dose of 50 mg/kg body weight), either with or without oral retinyl acetate (Rac, at a dose of 3000 IU) administration. Glutathione S-transferase activities were determined for microsomes (Panel B) and cytosol (Panel C) isolated from livers of mice 72 h after per os administration of corn oil (vehicle) or bisphenol A (BPA, at a dose of 50 mg/kg body weight), either with or without oral retinyl acetate (Rac, at a dose of 3000 IU) administration. Values marked with different letters (a, b, c, d) are statistically different, P < 0.05. All values are given as the mean ± 1 SD, n = 6 for each group.