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. 2017 Mar 9;26(10):1855–1862. doi: 10.1093/hmg/ddx088

Figure 4.

Figure 4

Diet-induced high Hcy brain level effects on synaptic integrity and neuroinflammation are rescued by genetic absence of ALOX5. (A) Representative western blot analyses of post-synaptic density protein 95 (PSD-95), synaptophysin (SYP), microtubule-associated protein 2 (MAP2), GFAP and CD45 in brain cortex homogenates from wild type mice receiving regular diet (WT); wild type mice receiving folate and B vitamin deficient diet (WT + Diet); 5LOKO mice receiving regular diet (5LOKO); and 5LOKO mice receiving the Diet (5LOKO + Diet). (B) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (*P < 0.05). Values represent mean ± S.E.M. (n = 5 WT-control; n = 5 WT + Diet; n = 5 5LOKO-control; n = 5 5LOKO + Diet).