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Restoration of SMN via ASO treatment corrects SMA spleen pathology. Representative images of spleen sections from PND 12 ASO-treated SMA mice (right), sham-treated SMA control (center), and WT control (left). (A) H&E staining, treated SMA spleen displays architecture and red pulp similar to WT. (B) Immunostaining for B lymphocytes using anti-B220. (C) Immunostaining for T lymphocytes using anti-CD3.
