TABLE 3.
Adjusted ORs (95% CIs) for the association between baseline plasma selenium concentration and diabetes, stratified by baseline characteristics1
| Tertile of mean ± SD baseline plasma selenium | |||||
|---|---|---|---|---|---|
| 113.5 ± 9.7 ng/mL | 135.4 ± 5.9 ng/mL | 168.7 ± 23.4 ng/mL | |||
| (n = 572) | (n = 571) | (n = 571) | P-trend2 | P-interaction | |
| Total population, n cases (%) | 43 (25.2) | 55 (32.2) | 73 (42.7) | ||
| Adjusted OR (95% CI) | 1.00 | 1.25 (0.80, 1.95) | 1.77 (1.16, 2.71) | 0.007 | |
| Age at baseline, n cases (%) | 0.15 | ||||
| <63 y | 11 (17.7) | 22 (35.5) | 29 (46.8) | ||
| Adjusted OR (95% CI) | 1.00 | 2.54 (1.07, 6.04) | 3.04 (1.32, 7.02) | 0.01 | |
| ≥63 y | 32 (29.4) | 33 (30.3) | 44 (40.4) | ||
| Adjusted OR (95% CI) | 1.00 | 0.95 (0.55, 1.65) | 1.41 (0.84, 2.37) | 0.18 | |
| Sex, n cases (%) | 0.87 | ||||
| Men | 29 (23.4) | 41 (33.1) | 54 (43.6) | ||
| Adjusted OR (95% CI) | 1.00 | 1.36 (0.80, 2.32) | 1.91 (1.15, 3.19) | 0.01 | |
| Women | 14 (29.8) | 14 (29.8) | 19 (40.4) | ||
| Adjusted OR (95% CI) | 1.00 | 1.30 (0.54, 3.11) | 2.02 (0.88, 4.63) | 0.09 | |
| BMI (kg/m2), n cases (%) | 0.85 | ||||
| <25 | 2 (20.0) | 4 (40.0) | 4 (40.0) | ||
| Adjusted OR (95% CI) | 1.00 | 1.43 (0.18, 11.16) | 1.47 (0.18, 11.87) | 0.73 | |
| 25 to <30 | 13 (25.5) | 17 (33.3) | 21 (41.2) | ||
| Adjusted OR (95% CI) | 1.00 | 1.29 (0.58, 2.84) | 1.43 (0.67, 3.06) | 0.36 | |
| ≥30 | 28 (25.5) | 34 (30.9) | 48 (43.6) | ||
| Adjusted OR (95% CI) | 1.00 | 1.04 (0.59, 1.85) | 1.73 (1.00, 2.99) | 0.04 | |
| Smoking | 0.43 | ||||
| Never | 14 (22.2) | 24 (38.1) | 25 (39.7) | ||
| Adjusted OR (95% CI) | 1.00 | 1.66 (0.77, 3.56) | 1.68 (0.79, 3.61) | 0.20 | |
| Former | 25 (28.1) | 24 (27.0) | 40 (44.9) | ||
| Adjusted OR (95% CI) | 1.00 | 0.92 (0.50, 1.72) | 1.65 (0.94, 2.91) | 0.07 | |
| Current | 2 (13.3) | 6 (40.0) | 7 (46.7) | ||
| Adjusted OR (95% CI) | 1.00 | 3.54 (0.52, 24.00) | 7.04 (1.04, 47.55) | 0.04 | |
| Ethnicity, n cases (%) | 0.12 | ||||
| Non-Hispanic/non-Latino | 38 (25.0) | 51 (33.6) | 63 (41.5) | ||
| Adjusted OR (95% CI) | 1.00 | 1.37 (0.86, 2.17) | 1.75 (1.12, 2.73) | 0.01 | |
| Hispanic/Latino | 5 (27.8) | 3 (16.7) | 10 (55.6) | ||
| Adjusted OR (95% CI) | 1.00 | 0.13 (0.01, 2.17) | 0.63 (0.06, 6.54) | 0.80 | |
1
Models adjusted for age, sex, BMI, race, ethnicity, smoking, education, and dietary intake of energy, protein, carbohydrate, total fat, and total fiber.
2
P values are P-trend for continuous variables.