Table 2.
Prostate cancer risk by genotypes of estrogen-related genes in the PCPT
| Gene | SNP | Genotype | Controls | Overall prostate cancer | Low-grade prostate cancer | High-grade prostate cancer | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | ORa (95% CI) | P trend | Cases | ORa (95% CI) | P trend | Cases | ORa (95% CI) | P trend | ||||
| Placebo arm | ||||||||||||
| ESR1 | rs1801132 | CC | 485 | 539 | 1.00 | 0.04 | 413 | 1.00 | 0.05 | 103 | 1.00 | 0.31 |
| CG | 310 | 281 | 0.81 (0.66–1.00) | 216 | 0.81 (0.66–1.01) | 55 | 0.85 (0.59–1.22) | |||||
| GG | 49 | 42 | 0.77 (0.50–1.19) | 32 | 0.76 (0.48–1.21) | 8 | 0.77 (0.35–1.68) | |||||
| per risk allele | 0.84 (0.72–0.99) | 0.84 (0.71–1.00) | 0.86 (0.65–1.15) | |||||||||
| Finasteride arm | ||||||||||||
| ESR2 | rs1256049 | GG | 485 | 576 | 1.00 | 0.36 | 343 | 1.00 | 0.72 | 211 | 1.00 | 0.01 |
| GA | 41 | 40 | 0.81 (0.51–1.27 | 32 | 1.09 (0.67–1.78) | 7 | 0.39 (0.17–0.87) | |||||
| AA | 0 | 0 | N/A | 0 | N/A | 0 | N/A | |||||
| per risk allele | ||||||||||||
| CYP17A1 | rs743572 | AA | 189 | 219 | 1.00 | 0.83 | 149 | 1.00 | 0.18 | 62 | 1.00 | 0.18 |
| AG | 259 | 323 | 1.08 (0.84–1.39) | 183 | 0.89 (0.67–1.18) | 129 | 1.50 (1.05–2.15) | |||||
| GG | 70 | 73 | 0.89 (0.61–1.31) | 41 | 0.74 (0.48–1.16) | 28 | 1.21 (0.71–2.04) | |||||
| per risk allele | 0.98 (0.82–1.17) | 0.87 (0.71–1.07) | 1.18 (0.93–1.50) | |||||||||
| CYP19A1 | rs2445765 | GG | 324 | 427 | 1.00 | 0.001 | 261 | 1.00 | 0.02 | 149 | 1.00 | 0.04 |
| GC | 175 | 174 | 0.75 (0.58–0.97) | 104 | 0.74 (0.55–0.99) | 65 | 0.82 (0.58–1.15) | |||||
| CC | 28 | 21 | 0.56 (0.31–1.01) | 15 | 0.63 (0.33–1.22) | 5 | 0.39 (0.15–1.02) | |||||
| per risk allele | 0.75 (0.61–0.92) | 0.76 (0.61–0.97) | 0.74 (0.56–0.99) | |||||||||
| COMT | rs4680 | AA | 121 | 105 | 1.00 | 0.06 | 58 | 1.00 | 0.03 | 42 | 1.00 | 0.73 |
| AG | 205 | 231 | 1.32 (0.96–1.83) | 154 | 1.61 (1.11–2.35) | 73 | 1.01 (0.65–1.58) | |||||
| GG | 91 | 113 | 1.44 (0.98–2.11) | 71 | 1.62 (1.03–2.52) | 35 | 1.10 (0.65–1.86) | |||||
| per risk allele | 1.20 (0.99–1.46) | 1.27 (1.02–1.58) | 1.05 (0.81–1.36) | |||||||||
Bold values indicate significant/borderline significant findings.
Adjusted for age and family history.