Table 1.
Characteristics of breast cancer patients in relation to CTCAE neuropathy grade (n = 1225) and neuropathy score as determined by the FACT/GOG-Ntx (n = 922)
| Characteristic | CTCAE neuropathy grade score |
FACT/GOG-Ntx score tertiles |
|||||
|---|---|---|---|---|---|---|---|
| 3–4 No. (%) | 0–2 No. (%) | P* | 3 No. (%) | 2 No. (%) | 1 No. (%) | P* | |
| Total, No. (%) | 152 (12.4) | 1073 (87.6) | -- | 321 (34.8) | 320 (34.7) | 281 (30.5) | -- |
| Age, y | .05 | .001 | |||||
| <40 | 37 (9.4) | 358 (90.6) | 17 (17.2) | 39 (39.4) | 43 (43.4) | ||
| 40–49 | 60 (14.0) | 368 (86.0) | 93 (32.4) | 98 (34.1) | 96 (33.4) | ||
| 50–59 | 41 (15.7) | 220 (84.3) | 128 (38.7) | 113 (34.1) | 90 (27.2) | ||
| ≥60 | 14 (9.9) | 127 (90.1) | 83 (40.5) | 70 (34.1) | 52 (25.4) | ||
| Race/ethnicity | .007 | .12 | |||||
| Non-Hispanic white | 110 (11.2) | 874 (88.8) | 251 (33.2) | 268 (35.4) | 237 (31.3) | ||
| Hispanic | 5 (8.8) | 52 (91.2) | 18 (54.5) | 5 (15.2) | 10 (30.3) | ||
| Black/African American | 17 (20.5) | 66 (79.5) | 22 (37.3) | 22 (37.3) | 15 (25.4) | ||
| Other | 20 (19.8) | 81 (80.2) | 30 (40.5) | 25 (33.8) | 19 (25.7) | ||
| Body mass index, kg/m2 | .21 | <.001 | |||||
| Underweight (≤18.5) | 0 (0) | 11 (100) | 2 (28.6) | 3 (42.9) | 2 (28.6) | ||
| Normal (18.5–24.9) | 36 (10.5) | 308 (89.5) | 72 (26.9) | 81 (30.2) | 115 (42.9) | ||
| Overweight (25–29.9) | 68 (14.4) | 403 (85.6) | 142 (41.0) | 125 (36.1) | 79 (22.8) | ||
| Obese (≥30) | 47 (12.2) | 337 (87.8) | 105 (36.0) | 106 (36.3) | 81 (27.7) | ||
| Menopausal status, No. | .02 | ||||||
| Premenopausal | 57 (10.1) | 510 (89.9) | 124 (29.7) | 145 (34.8) | 148 (35.5) | ||
| Postmenopausal | 95 (14.4) | 563 (85.6) | 197 (39.0) | 175 (34.7) | 133 (26.3) | ||
| Smoking history | .90 | .02 | |||||
| Never smoker | 80 (12.0) | 584 (88.0) | 158 (30.9) | 184 (35.9) | 170 (33.2) | ||
| Former smoker | 51 (12.8) | 347 (87.2) | 111 (37.4) | 103 (34.7) | 83 (27.9) | ||
| Current smoker | 20 (13.2) | 132 (86.8) | 50 (46.3) | 50 (46.3) | 27 (25.0) | ||
| Education | .07 | .02 | |||||
| < High school graduate | 18 (20.5) | 70 (79.5) | 23 (41.1) | 12 (21.4) | 21 (37.5) | ||
| High school graduate or GED | 33 (12.6) | 228 (87.4) | 72 (36.5) | 74 (37.6) | 51 (25.9) | ||
| Some college | 56 (12.9) | 377 (87.1) | 130 (39.5) | 104 (31.6) | 95 (28.9) | ||
| College graduate | 23 (8.7) | 242 (91.3) | 63 (31.0) | 71 (35.0) | 69 (34.0) | ||
| Advanced degree | 22 (12.7) | 151 (87.3) | 33 (24.6) | 57 (32.8) | 44 (32.8) | ||
| Marital status | .11 | .14 | |||||
| Married or living as married | 105 (11.8) | 786 (88.2) | 234 (33.7) | 231 (33.3) | 229 (33.0) | ||
| Widowed | 12 (21.1) | 5 (78.9) | 12 (31.6) | 15 (39.5) | 11 (28.9) | ||
| Separated or divorced | 29 (14.5) | 171 (85.5) | 55 (40.7) | 53 (39.3) | 27 (20.0) | ||
| Single | 6 (8.5) | 65 (91.5) | 18 (35.3) | 19 (37.3) | 14 (27.5) | ||
| Physical activity† | .82 | .19 | |||||
| No | 28 (12.0) | 206 (88.0) | 69 (40.8) | 54 (32.0) | 46 (27.2) | ||
| Yes | 124 (12.5) | 867 (87.5) | 252 (33.5) | 266 (35.3) | 235 (31.2) | ||
| Treatment arm‡ | .003 | .25 | |||||
| 1 | 39 (16.0) | 205 (84.0) | 77 (40.1) | 66 (34.4) | 49 (25.5) | ||
| 2 | 36 (16.6) | 181 (83.4) | 58 (34.7) | 59 (35.3) | 50 (29.9) | ||
| 3 | 21 (8.1) | 238 (91.9) | 73 (36.7) | 59 (29.6) | 67 (33.7) | ||
| 4 | 19 (8.0) | 218 (92.0) | 52 (30.4) | 66 (38.6) | 53 (31.0) | ||
| 5 | 21 (17.6) | 98 (82.4) | 25 (29.1) | 38 (44.2) | 23 (26.7) | ||
| 6 | 16 (10.7) | 133 (89.3) | 36 (33.6) | 32 (29.9) | 39 (36.4) | ||
| CTCAE grade | − | − | <.001 | ||||
| 0–2 | − | − | 243 (30.3) | 290 (36.1) | 270 (33.6) | ||
| 3–4 | − | 78 (65.5) | 30 (25.2) | 11 (9.2) | |||
*
P values were computed using two-sided chi-square tests. CTCAE = Common Terminology Criteria for Adverse Events; FACT/GOG-Ntx = Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity.
†
In month before diagnosis.
‡
Treatment arms correspond to the descriptions given in Figure 1.