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. 2017 Mar 13;26(10):1890–1899. doi: 10.1093/hmg/ddx097

Figure 5.

Figure 5

 Effects of EX-527 on hepatic STAT3/NFκB targets in wild-type and AAV-NT mice. Wild-type and AAV-NT mice at age 64–74 weeks were treated with EX-527 for 4 weeks, and their phenotype analyzed at age 68–78 weeks. For densitometry analysis, the data were analyzed from 4 pairs of wild-type/AAV-NT and wild-type-EX-527/AAV-NT-EX-527 mice. (A) Western blot analysis of NOS2, survivin, and β-actin with quantification of protein levels by densitometry. (B) Immunofluorescence analysis of hepatic cells stained positive for F4/80 that detects macrophages and quantification of F4/80-positive cells. Representative plates shown are analyzed for 4 pairs of wild-type/AAV-NT and wild-type-EX-527/AAV-NT-EX-527 mice. Scale bar: 25 μm. Data represent the mean ± SEM; *P < 0.05; **P < 0.005.