Table 2. Univariate/multivariate COX regression analyses of clinicopathologic factors associated with RFS in the TCGA cohort.
| Variables | Univariate analysis | Multivariate analysis | |||
| HR (95% CI) | P | HR (95% CI) | P | ||
| Three-lncRNA risk score | 1.34 (1.02-1.76) | 0.034* | 1.74 (1.20-2.52) | 0.004* | |
| TNM stage (II/I) | 1.76 (1.18-2.62) | 0.006* | 1.44 (0.89-2.34) | 0.14 | |
| Gender (male/female) | 0.92 (0.60-1.39) | 0.68 | — | — | |
| Age (>60/≤60 years) | 0.87 (0.59-1.29) | 0.48 | — | — | |
| HBV (Yes/No) | 0.67 (0.43-1.02) | 0.062 | — | — | |
| Alcohol consumption (Yes/No) | 0.79 (0.50-1.25) | 0.31 | — | — | |
| Liver cirrhosis (Yes/No) | 1.69 (1.06-2.70) | 0.028* | 1.71 (1.06-2.75) | 0.028* | |
| Albumin (≥4.0/<4.0 g/dl) | 1.39 (0.92-2.08) | 0.12 | — | — | |
| Creatinine (≥1.1/<1.1 mg/dl) | 0.70 (0.45-1.09) | 0.11 | — | — | |
| AFP a (>20/≤20 ng/ml) | 1.18 (0.77-1.80) | 0.45 | — | — | |
| Platelet (≥200/<200×109/L) | 1.16 (0.77-1.74) | 0.48 | — | — | |
| Race (Asian/not Asian) | 0.79 (0.53-1.18) | 0.25 | — | — | |
| BMI b (≥25/<25 kg/m2) | 1.01 (0.68-1.52) | 0.95 | — | — | |
| Family history (Yes/No) | 0.98 (0.62-1.53) | 0.92 | — | — | |
| ECOG c (>0/0) | 1.49 (1.09-2.04) | 0.013* | 1.56 (1.03-2.37) | 0.036* | |
| Histological grade (G3-4/G1-2) | 1.06 (0.71-1.59) | 0.78 | — | — | |
| Adjacent tissue inflammation (Yes/No) | 1.43 (0.90-2.25) | 0.13 | — | — | |
| TP53 mutation (Yes/No) | 1.21 (0.79-1.85) | 0.38 | — | — | |
| PYK2B expression | 1.02 (0.89-1.18) | 0.74 | — | — | |
Abbreviations: RFS, recurrence-free survival; HR, hazard ratio; 95% CI, 95% confidence interval.
*:Statistically significant; a:Alpha-fetoprotein; b:body mass index; c:Eastern Cooperative Oncology Group.