Table I.
Characteristics of EAGeR population by pregnancy status.
| Overall | No observed pregnancy | hCG-detected pregnancy | Ultrasound-confirmed pregnancy | Withdrawal | LDL cholesterol | ||
|---|---|---|---|---|---|---|---|
| (n = 1228) No. (%) | (n = 303) No. (%) | (n = 797) No. (%) | (n = 732) No. (%) | (n = 128) No. (%) | <130 mg/dl (n = 1094) No. (%) |
≥130 mg/dl (n = 94) No. (%) |
|
| Maternal age, mean (range) | 28.7 (18.7–40.8) | 29.4 (19.2–40.8) | 28.7 (18.8–40.8)a | 28.6 (19.1–40.3)b | 27.5 (18.7–40.0)c | 28.6 (18.7–40.8) | 29.8 (19.7–39.7)d |
| BMI, mean (range) | 26.4 (15.7–58.7) | 27.8 (16.4–58.5) | 25.5 (115–55.0)a | 25.5 (15.7–55.0)b | 28.1 (17.5–58.7)c | 25.9 (15.7–58.7) | 30.3 (18.9–44.7)d |
| Waist–hip ratio, mean (range) | 0.81 (0.48–1.09) | 0.81 (0.65–1.09) | 0.81 (0.59–1.04) | 0.80 (0.59–1.04) | 0.82 (0.48–1.06)c | 0.81 (0.48–1.09) | 0.86 (0.67–1.06)d |
| Race | |||||||
| White | 1162 (94.6) | 283 (93.4) | 769 (96.5)a | 696 (96.7) | 110 (85.9)c | 1035 (94.6) | 90 (95.7) |
| Non-White | 66 (5.4) | 20 (6.6) | 28 (3.5) | 24 (3.3) | 18 (14.1) | 59 (5.4) | 4 (4.3) |
| Missing | 0 (0) | ||||||
| Marital status | |||||||
| Married | 1124 (91.5) | 272 (89.8) | 752 (94.3)a | 683 (94.9)b | 100 (78.1)c | 1007 (92.1) | 82 (87.3) |
| Living with partner | 74 (6.0) | 27 (8.9) | 31 (3.9) | 26 (3.6) | 16 (12.5) | 64 (5.9) | 7 (7.5) |
| Other | 30 (2.5) | 4 (1.3) | 14 (1.8) | 11 (1.5) | 12 (9.4) | 23 (2.1) | 5 (5.3) |
| Missing | 0 (0) | ||||||
| Education | |||||||
| Beyond high school | 1082 (88.2) | 260 (85.8) | 707 (88.7) | 644 (89.4) | 90 (70.9)c | 1073 (98.2) | 91 (96.8) |
| Up to high school | 145 (11.8) | 43 (14.2) | 89 (11.3) | 76 (10.6) | 37 (29.1) | 20 (1.8) | 3 (3.2) |
| Missing | 1 (0.08) | ||||||
| Annual household income (US$) | |||||||
| ≥100 000 | 491 (40.0) | 133 (44.0) | 326 (40.9) | 296 (41.1) | 32 (25.0)c | 440 (40.3) | 35 (37.3) |
| 75–99 999 | 149 (12.1) | 26 (8.6) | 114 (14.3) | 102 (14.2) | 9 (7.0) | 131 (12.0) | 15 (15.9) |
| 40–74 999 | 181 (14.8) | 46 (15.2) | 116 (14.5) | 106 (14.7) | 19 (14.8) | 162 (14.8) | 12 (12.8) |
| 20–39 999 | 312 (25.4) | 81 (26.8) | 187 (23.5) | 169 (23.5) | 44 (34.4) | 273 (24.9) | 27 (28.7) |
| ≤19 999 | 94 (7.7) | 16 (5.3) | 54 (6.8) | 47 (6.5) | 24 (18.8) | 87 (7.9) | 5 (5.3) |
| Missing | 1 (0.08) | ||||||
| Employment | |||||||
| Employed | 895 (72.9) | 238 (78.6) | 576 (72.3)a | 513 (71.3)b | 81 (63.3)c | 801 (73.2) | 70 (74.5) |
| Unemployed | 289 (23.5) | 58 (19.1) | 209 (26.2) | 195 (27.1) | 22 (17.2) | 254 (23.2) | 21 (22.3) |
| Missing | 44 (3.6) | ||||||
| Number of previous live births | |||||||
| 0 | 571 (46.5) | 166 (54.8) | 341 (42.8)a | 304 (42.2)b | 70 (54.7) | 499 (45.6) | 51 (54.3) |
| 1 | 443 (36.1) | 93 (30.7) | 301 (37.8) | 274 (38.1) | 44 (34.4) | 405 (37.0) | 26 (27.6) |
| 2 | 214 (17.4) | 44 (14.5) | 155 (19.5) | 142 (19.8) | 14 (10.9) | 190 (17.3) | 17 (18.1) |
| Missing | 0 (0) | ||||||
| Number of previous pregnancy losses | |||||||
| 1 | 825 (67.2) | 216 (71.3) | 524 (65.8) | 476 (66.1) | 85 (66.4) | 736 (67.3) | 64 (68.1) |
| 2 | 403 (32.8) | 87 (28.7) | 273 (34.3) | 244 (33.9) | 43 (33.6) | 358 (32.7) | 30 (31.9) |
| Missing | 0 (0) | ||||||
| Alcohol consumption in the past year | |||||||
| Never | 806 (66.5) | 202 (67.3) | 532 (67.4) | 480 (67.4) | 72 (58.5)c | 720 (66.6) | 58 (63.1) |
| Sometimes | 380 (31.4) | 93 (31.0) | 238 (30.2) | 213 (29.9) | 49 (39.4) | 336 (31.1) | 34 (36.9) |
| Often | 26 (2.1) | 5 (1.6) | 19 (2.4) | 19 (2.7) | 2 (1.6) | 25 (2.3) | 0 (0) |
| Missing | 16 (1.3) | ||||||
| Fasting status | |||||||
| Fasting | 179 (14.6) | 55 (18.4) | 95 (12.1)a | 90 (12.5)b | 29 (24.0)c | 151 (14.0) | 24 (26.7)d |
| Non-fasting | 1027 (83.6) | 244 (81.6) | 691 (87.9) | 632 (87.5) | 92 (76.0) | 926 (86.0) | 66 (73.3) |
| Missing | 22 (1.8) | ||||||
| Treatment group | |||||||
| Placebo | 613 (49.9) | 171 (56.4) | 385 (48.3)a | 354 (48.3)b | 57 (44.5) | 547 (50.0) | 42 (44.7) |
| Low-dose aspirin | 615 (50.1) | 132 (43.6) | 412 (51.7) | 378 (51.6) | 71 (55.5) | 547 (50.0) | 52 (55.3) |
EAGeR, Effects of Aspirin in Gestation and Reproduction; LDL, low-density lipoprotein.
aP < 0.05 between hCG-detected pregnancy and no observed pregnancy.
bP < 0.05 between ultrasound-confirmed pregnancy and no observed pregnancy.
cP < 0.05 between withdrawal and any observed pregnancy (hCG-detected or ultrasound-confirmed).
dP< 0.05 between LDL < 130 and LDL ≥ 130.