Table 2.
Cross-sectional (age 73 y) and longitudinal (age 73 y to age 76 y) associations between S100β and MRI variables
| Variable | Cross-sectional (age 73 y) | 95% CI |
Longitudinal (age 73–76 y) | 95% CI |
||
|---|---|---|---|---|---|---|
| Lower | Upper | Lower | Upper | |||
| WMHa | −0.019 (0.634) | −0.092 | 0.074 | 0.082 (0.095) | 0.002 | 0.174 |
| PVS | −0.034 (0.475)b | −0.132 | 0.050 | −0.096 (0.041)b | −0.183 | −0.007 |
| gFA | −0.150 (0.001) | −0.233 | −0.065 | −0.083 (0.154) | −0.199 | 0.038 |
| gMD | 0.003 (0.941) | −0.099 | 0.114 | −0.019 (0.717) | −0.135 | 0.075 |
| GM | 0.061 (0.133) | −0.021 | 0.127 | −0.050 (0.309) | −0.138 | 0.049 |
| TBV | 0.045 (0.272) | −0.024 | 0.125 | −0.044 (0.364) | −0.136 | 0.044 |
Data are shown as standardized coefficients (p values), with bootstrapped 95% confidence intervals (CIs) from 1000 draws.
Bold text indicates FDR q < 0.05.
Key: FDR, false discovery rate; gFA, general factor of white matter tract fractional anisotropy; gMD, general factor of white matter tract mean diffusivity; GM, gray matter volume; PVS, perivascular space rating; TBV, total brain volume; WMH, white matter hyperintensity volume.
a
log transformed.
b
coefficients are for associations between visually rated PVS change (rather than a latent change score) with S100β level and change.