Table E4.
Microbial taxa associated with atopic wheezing corrected for major confounding effects known to affect microbiome composition by using MaAsLin
| Variable | Feature | Coefficient | P value (adjusted) | q Value | Effect | 95% CI |
|---|---|---|---|---|---|---|
| Bacterial features | ||||||
| Phenotype | Bifidobacterium_179 | 0.02299582 | 1.05E-12 | 8.64E-11 | Increased | 0.02169825 to 0.0242934 |
| Phenotype | Veillonella_Dispar_132 | −0.0092217 | .00254641 | 0.10440262 | Decreased | −0.0106249 to −0.0078185 |
| Phenotype | Veillonella_86 | −0.007847 | .02938598 | 0.6277335 | Decreased | −0.0094878 to −0.0062061 |
| Phenotype | Veillonella_26 | −0.0167265 | .03077532 | 0.6277335 | Decreased | −0.0201968 to −0.0132562 |
| Phenotype | Streptococcus_135 | −0.0050144 | .0444958 | 0.6277335 | Decreased | −0.0071267 to −0.0029021 |
| Phenotype | Bifidobacterium_103 | 0.00845423 | .04751864 | 0.6277335 | Increased | 0.00639847 to 0.01050998 |
| Fungal features | ||||||
| Phenotype | Pichia_Kudriavzevii_1538 | −0.2039807 | .00325965 | 0.08131335 | Decreased | −0.2268391 to 0.28743912 |
| Phenotype | Pichia_Kudriavzevii_1534 | −0.035631 | .00350364 | 0.08131335 | Decreased | −0.0396671 to 0.05036711 |
| Phenotype | Pichia_Kudriavzevii_1531 | −0.0358471 | .00431312 | 0.08131335 | Decreased | −0.040034 to 0.05113405 |
| Phenotype | Pichia_Kudriavzevii_1533 | −0.0309382 | .00496049 | 0.08131335 | Decreased | −0.0346121 to 0.04435211 |
| Phenotype | Pichia_Kudriavzevii_1539 | −0.0321617 | .00555307 | 0.08131335 | Decreased | −0.0360469 to 0.04634688 |
| Phenotype | Pichia_Kudriavzevii_1541 | −0.0250888 | .00638293 | 0.08131335 | Decreased | −0.0281781 to 0.0363681 |
| Phenotype | Pichia_Kudriavzevii_1540 | −0.0309761 | .00694138 | 0.08131335 | Decreased | −0.0348236 to 0.04502356 |
| Phenotype | Saccharomyces_1327 | −0.1066187 | .0088887 | 0.09110916 | Decreased | −0.1204243 to 0.15702429 |
| Phenotype | Aspergillus_flavus_1703 | −0.2422061 | .02612342 | 0.22469852 | Decreased | −0.2799263 to 0.37992633 |
| Phenotype | Aspergillus_flavus_1631 | −0.2258779 | .02740226 | 0.22469852 | Decreased | −0.2615235 to 0.35602348 |
| Phenotype | Saccharomycetales_Uncultured_716 | −0.1691154 | .03545843 | 0.26432651 | Decreased | −0.1853351 to 0.22833514 |
| Phenotype | Saccharomycetales_Uncultured_717 | −0.1835183 | .04168681 | 0.26766654 | Decreased | −0.1899307 to 0.20693072 |
| Phenotype | Leotiomycetes_Uncultured_1500 | −0.0163321 | .04646276 | 0.26766654 | Decreased | −0.0223673 to 0.03836733 |
Direction of the correlation coefficient is in relation to the control group. P values are corrected for false discovery rate. Boldface represents the same OTUs identified as significant by using DESeq2 analysis (see Table E3).