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. 2017 Feb 7;26(5):901–912. doi: 10.1093/hmg/ddx005

Figure 4.

Figure 4

Effects of TSPY and TSPX expression in prostate cancer LNCaP cells in the presence of the synthetic ligand R1881. (A) TSPY promotes and TSPX inhibits cell proliferation, as compared to EGFP alone, in LNCaP cells. (B) qRT-PCR analysis of five endogenous androgen-responsive genes (KLK3, TMPRSS2, FKBP5, NKX3.1, KLK2) and HPRT control in the above transduced LNCaP cells. (C–D) Chromatin immunoprecipitation assays confirm TSPY (C) and TSPX (D) are co-localized with AR in bindings to the promoters of the five androgen-responsive genes in LNCaP cells in the presence of R1881.