Figure 4.

Plasmodium falciparum–specific immunoglobulin G (IgG) reactivity decreases during the dry season irrespective of P. falciparum infection status. A, Breadth of IgG response in January and May 2012, stratified by P. falciparum infection status in May 2012. B, Magnitude of IgG reactivity in January and May 2012, stratified by P. falciparum infection status in May 2012. C, Magnitude of IgG response in January and May 2012 for antigens that were reactive at both timepoints (2 standard deviations (SDs) above the no DNA control), stratified by P. falciparum infection status in May 2012. D, Proportion of antigens to which the level of IgG reactivity fell below the level of detection between January and May 2012, stratified by P. falciparum infection status in May 2012. E, Change in magnitude of IgG reactivity for antigens that were reactive in January and May 2012, stratified by P. falciparum infection status in May 2012. Breadth is defined as the number of antigens to which the level of IgG reactivity exceeds 2 SDs above the no DNA control. Magnitude is defined as the sum of log₂-IgG intensity values for all antigens per sample. Boxes indicate median and 25th and 75th percentiles. Values >1.5 times the interquartile range are plotted as individual points (Tukey method). P values less than .05 were considered statistically significant. Abbreviations: IgG, immunoglobulin G; PCR, polymerase chain reaction; RDT, rapid diagnostic test.