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. 2016 Oct 25;26(1):52–64. doi: 10.1093/hmg/ddw367

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Published by Oxford University Press 2016. This work is written by US Government employees and is in the public domain in the US.

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Figure 2. — Survival of Npc1^-/- mice and growth following AAV9 treatment. (A) Kaplan-Meier Curve depicts survival of: Npc1^-/- pups (n = 6) treated with 2.6 × 10¹¹ GC of AAV9-CamKII-NPC1 between 1 and 3 days, Npc1^-/- mice (n = 9) treated with 1.3 × 10¹² GC of AAV9-CamKII-NPC1 between 20 and 25 days of life, Npc1^-/- mice (n = 6) treated with 1.2 × 10¹² GC of AAV9-CamKII-GFP between 20 and 25 days of life and untreated Npc1^-/- mice (n = 16). (B) Survival data depicted as a vertical scatter plot to show survival distribution. (C) Week at which Npc1^-/- mice reached peak weight. (D) Percentage weight change between weeks 6 and 9. **P < 0.01, ***P < 0.001, Log-ranked (Mantel Cox) test or t-test two-tailed.