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. 2016 Oct 25;26(1):52–64. doi: 10.1093/hmg/ddw367

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Published by Oxford University Press 2016. This work is written by US Government employees and is in the public domain in the US.

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Figure 6. — AAV9-EF1a-NPC1 treatment increase survival and growth in Npc1^-/- mice. (A) Kaplan-Meier curve depicts survival of: untreated Npc1^-/- mice (n = 16), Npc1^-/- mice (n = 9) treated with 1.3 × 10¹² GC of AAV9-CamKII-NPC1 between 20 and 25 days of life, and Npc1^-/- mice (n = 7) treated with 1.2 × 10¹² GC of AAV9-EF1a-NPC1 between 20 and 25 days of life. (B) Week at which Npc1^-/- mice reached peak weight. (C) Percentage weight change between weeks 6 and 9. ** P < 0.01, ***P < 0.001, Log-ranked (Mantel Cox) test or t-test two-tailed. The arrow on the X-axis indicates the date nutragel was added to the pellet diet for two of the three mice.