Table 3.

Physical Activity Index and the Risk of Alzheimer’s Disease (Framingham Original and Offspring cohorts)

	Cases / N	188 / 3,714	p Value	171 / 3,542	p Value	153 / 2,958	p Value
		HR (95% CI)		HR (95% CI)		HR (95% CI)
		Age and Sex Adjusted		Age, Sex, and APOEε4 Adjusted		Multivariable Adjusteda
Alzheimer’s disease	Per SD	1.06 (0.92–1.23)	.709	1.11 (0.96–1.29)	.153	1.10 (0.95–1.29)	.214
	Q1	1.00 (Referent)		1.00 (Referent)		1.00 (Referent)
	Q2	0.49 (0.30–0.79)	.003	0.49 (0.29–0.83)	.008	0.44 (0.25–0.78)	.005
	Q3	0.73 (0.48–1.13)	.157	0.81 (0.52–1.27)	.350	0.91 (0.57–1.46)	.705
	Q4	0.71 (0.45–1.10)	.120	0.72 (0.45–1.15)	.163	0.74 (0.45–1.23)	.251
	Q5	0.90 (0.59–1.37)	.612	0.98 (0.63–1.52)	.930	0.93 (0.58–1.49)	.758
	Q1 vs. Q2–Q5	1.44 (1.04–2.00)	.029	1.35 (0.95–1.92)	.097	1.34 (0.92–1.95)	.129

Notes: APO = apolipoprotein; CI = confidence interval; HR = hazard ratio; Q = quartile.

^aAdjusted for age, sex, high school degree, APOEε4 allele status, log plasma homocysteine, systolic blood pressure, diastolic blood pressure, antihypertensive medication, total cholesterol, current smoking, prevalent cardiovascular disease, diabetes, stroke, and atrial fibrillation.

p Values less than .05 are bolded to highlight statistical significance.