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. 2017 Feb 1;26(8):1407–1418. doi: 10.1093/hmg/ddx035

Figure 1.

Figure 1

Part of TDP-43 enriched granules may contain translational machinery. (A) Embryonic hippocampal mouse cells immunolabeled by TDP-43 and RACK1. RACK1 has been used to indicate ribosomes and polyribosomes. Magnification of boxed regions is reported in a. The heads of arrows indicate the partial or adjacent co-localization of TDP-43 and RACK1, while the arrows indicate the full co-localization of TDP-43/RACK1. 1 is magnification of regions indicated by the heads and the arrows. Scale bar=10 µm. (B) Graph reporting the correlation measured by Pearson coefficient of the puncta signal between TDP-43 and RACK1 (TDP-43 graph bar) and that between rpS6 and RACK1 (rpS6 graph bar). All bar represent mean ± SD; n=70 puncta from three independent experiments. Blue = DAPI.