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. 2017 Feb 21;26(11):1979–1991. doi: 10.1093/hmg/ddx065

Figure 6.

Figure 6

Lack of AnxA2 improves dysferlinopathic muscle function. (A,B) Forelimb and hindlimb grip strength (GSM) measurement of B6A/J or B6A/JA2 mice at < 6 months and WT, B6A/J or B6A/JA2 at >20 months (n > 10 animals). (C) Percentage of initial force as a result of successive 10% ex vivo lengthening contractions of B6A/J or B6A/JA2 Extensor Digitorum Longus (EDL) muscle from 6 months or 1-year-old animal (n > 4 animals). (D) Specific force of EDL muscle from B6A/J or B6A/JA2 mice at 6, 12 and 24 months (n > 6 animals). (E–G) Voluntary locomotor activity assessed by open-field behavioral activity measurements of B6A/J or B6A/JA2 mice at < 6 months and WT, B6A/J or B6A/JA2 mice at >20 months (n > 10 animals). Box whisker plots show median ± extreme values, while line plot (C) shows means ± S.E.M. A, B, E-G: *P ≤ 0.05 and ***P ≤ 0.001 compared to WT and $P ≤ 0.05, $$P ≤ 0.01 and $$$P≤ 0.001 compared to B6A/J by Kruskal Wallis test; C: *P ≤ 0.05, **P ≤ 0.01 and ***P ≤ 0.001 compared to B6A/J by ANOVA.