FIG. 3.

Genetic mapping using ALT fold change identifies significantly associated locus on chromosome 14. A, Genome scan plot illustrating QTL associated with tolvaptan-induced ALT fold change. Dashed horizontal lines indicate genome wide significance at the 0.01, 0.05, and 0.1 levels. An arrow points to the genomic interval with the highest LOD score (Marker: JAX00381082, Chr14: 59.47 Mb). B, Founder strain probabilities at the locus peak. The x-axis plots paired animals in order from left to right by increasing ln(ALT fold change). Each horizontal row indicates the probability of a given CC founder haplotype being present at the locus, with darker intensities indicating higher probabilities (0–1.0). C, Estimates and CIs for haplotype substitution effects at the peak locus. D, CI plot for the QTL on chromosome 14. The 80% CI (Chr14: 58.27–69.85 Mb) is spanned by black bars.