Skip to main content
. 2017 Apr 3;26(12):2299–2306. doi: 10.1093/hmg/ddx121

Figure 2.

Figure 2.

Retinal degeneration of Pde6g-/- mice is delayed in the Cngb1-/- background. (A) Retinal morphology of age-matched Cngb1-/-, Pde6g-/- and Pde6g-/-Cngb1-/- mice at age 2, 3 and 4 weeks. Rod death is much more rapid in the Pde6g-/- retina when compared to that of Cngb1-/- mice, and abolishing CNG channel expression in Pde6g-/- retinae substantially slowed rod death. RPE, retinal pigmented epithelium; OS: outer segment; IS, inner segment; ONL, outer nuclear layer; INL, inner nuclear layer. (B) Quantification of ONL thickness (mean ± SD, N ≥ 3) across the entire span of the central retina from the indicated mice at 2, 3 and 4 weeks of age. Squares: Cngb1-/-; diamonds: Pde6g-/-Cngb1-/-; triangles, Pde6g-/-. S: superior; I, inferior; O, optic nerve. (C). Retinal morphology of Pde6g-/- Cngb1-/- mice at age 5, 6 and 8 weeks. Scale bars = 20 μm.