Table 3.

Summary of regression analysis for association with cortical thickness in Alzheimer’s disease-vulnerable regions

	Model 1				Model 2				Model 3
Variable	B	SE(B)	β	P	B	SE(B)	β	P	B	SE(B)	β	P
Age	−0.005	0.001	−0.350	<0.001**	−0.005	0.001	−0.350	<0.001**	−0.005	0.001	−0.347	<0.001**
Sex	0.018	0.038	0.035	0.641	0.018	0.038	0.037	0.624	0.028	0.037	0.056	0.454
WTAR	0.001	0.000	0.098	0.200	0.001	0.000	0.100	0.186	0.001	0.000	0.126	0.094
PSQI	−0.027	0.022	−0.095	0.232	−0.018	0.022	−0.066	0.404	−0.018	0.022	−0.064	0.413
Lifetime PTSD	−0.130	0.22	−0.047	0.557	−0.009	0.023	−0.033	0.694	−0.011	0.022	−0.039	0.629
Lifetime mild TBI					−0.035	0.021	−0.131	0.096	0.279	0.135	1.05	0.04*
PRS-AD					−0.002	0.001	−0.146	0.052	0.002	0.002	0.116	0.384
mTBI × PRS-AD									−0.006	0.003	−1.21	0.019a,*
R2		0.146				0.182				0.212
F for ΔR2		5.246*				3.425*				5.579*

mTBI = mild traumatic brain injury; PRS-AD = polygenic risk score for Alzheimer’s disease.

^aCorrected value of this interaction term = 0.048 at the PRS-AD threshold P < 0.2. ^*P < 0.05, ^**P < 0.01. SE=standard error.