Table 2.

Selection of recent studies showing monotonic reduction of cortical thickness

	N /scans	Age range (years)	Cross versus long	Processing	Measure unit	Central finding	Google scholar citations
Amlien et al. (2014) , Cereb Cortex.	331/331	4–30	Cross	FS	Vertex, ROI	Continuous decrease entire cortex	0
Brown and Jernigan (2012) , Curr Biol.	885/885	3–20	Cross	FS	Vertex	Continuous decrease entire cortex	32
Brown et al. (2012) , Neuropsychol Rev.	202/202	4–20	Cross	FS	ROI	Continuous decrease total cortex	63
Mills et al. (2014) , Soc Cogn Affect Neurosci.	288/857	7–30	Long	FS	ROI	Linear decrease in 3 of 4 ROIs, increased thickness of the temporal pole until ≈20 years	35
Mutlu et al. (2013) , Neuroimage.	137/209	6–30	Long	FS	Vertex, ROI	Vertex-wise effects divided into linear, quadratic, cubic, and none show trajectories for 3 ROIs, all continuously decreasing	18
Zielinski et al. (2014) a , Brain.	157/345	3–39	Long	FS	ROI	Continuous decrease entire cortex	16
Nguyen et al. (2013) , Cereb Cortex.	281/281	4–22	Cross	CIVET	Vertex	Linear decrease entire cortex	12
Wierenga et al. (2014) , NeuroImage.	135/201	7–23	Long	FS	ROI	Linear decrease most ROIs, few quadratic, or cubic, mostly U-shaped	16
Wendelken et al. (2011) , J Neurosci.	85/85	6–18	Cross	FS	ROI	Linear decrease	26
van Soelen et al. (2012) , NeuroImage.	190/315	9 and 12	Long	CLASP	Vertex	No areas of thickening	42
Shaw, Lerch et al. (2006) , Arch Gen Psychiatr.	163 ADHD, 166 CTRL	Mean 8.9 at entry	Long	CIVET	Vertex	Different (through all declining) slopes of thickness	404
Gogtay et al. (2007) , Arch Gen Psychiatr.	52/113	8–28	Long	CIVET	Vertex	“Cortical deficits” relate to GAS scores; siblings catch up at 20 years	113

Note: Samples across publications are in some cases overlapping. Google scholar citations retrieved April 2015.

FS, FreeSurfer; ROI, regions of interest; GAS, Global Assessment Scale.

^a Ninety-seven autistic and 60 normal males, both groups showed thinning.