Table 1.

Summary of allelic effects at KLKB1 and F12 on circulating chromogranin A (CHGA) and B (CHGB) fragments, showing results for the lead SNPs at the chromosome 4 and 5 loci for the UCSD and QIMR cohorts and results from meta-analysis.

SNP	Chr	BP (Build 37)	Gene	Phenotype	Subjects	A1/A2	Freq A1	Beta	SE beta	P-value	p Meta	p Het
rs4253311	4	187,174,683	KLKB1	CHGA 361–372	UCSD	G/A	0.501	0.439	0.065	5.65 × 10−13	3.40 × 10−30	0.347
				CHGA 361–372	QIMR	G/A	0.511	0.447	0.047	9.07 × 10−22
				CHGA 116–439	UCSD	G/A	0.501	−0.205	0.066	0.0014	0.0011	0.346
				CHGA 116–439	QIMR	G/A	0.511	−0.116	0.060	0.054
				CHGA 116–130	UCSD	G/A	0.501	−0.030	0.088	0.820	–	–
				CHGB 312–331	UCSD	G/A	0.501	0.029	0.066	0.555	–	–
				CHGB 439–451	UCSD	G/A	0.501	0.331	0.071	1.45 × 10−6	1.39 × 10−7	0.044
				CHGB 439–451	QIMR	G/A	0.511	0.156	0.046	6.5 × 10−4
				CHGB 568–577	UCSD	G/A	0.501	0.642	0.089	1.53 × 10−12	–	–
rs2731672	5	176,842,474	F12	CHGA 361–372	UCSD	C/T	0.759	0.327	0.075	7.35 × 10−6	1.85 × 10−19	0.038
				CHGA 361–372	QIMR	C/T	0.747	0.462	0.056	8.58 × 10−17
				CHGA 116–439	UCSD	C/T	0.759	−0.180	0.074	0.016	0.0022	0.843
				CHGA 116–439	QIMR	C/T	0.747	−0.158	0.073	0.031
				CHGA 116–130	UCSD	C/T	0.759	0.190	0.106	0.095	–	–
				CHGB 312–331	UCSD	C/T	0.759	0.058	0.081	0.437	–	–
				CHGB 439–451	UCSD	C/T	0.759	0.252	0.087	0.0034	2.93 × 10−4	0.278
				CHGB 439–451	QIMR	C/T	0.747	0.138	0.054	0.011
				CHGB 568–577	UCSD	C/T	0.759	0.464	0.107	2.70 × 10−5	–	–