Table 3.

Dex-induced genes related to MAPK pathways

Probe ID	Gene Symbol	C7-14				C1-6				C1-15
		2 hr	8 hr	12 hr	20 hr	2 hr	8 hr	12 hr	20 hr	2 hr	8 hr	12 hr	20 hr
735_s_at	AKAP13	−1.0	1.2	2.5*	3.4*	1.3	2.6*	2.6*	3.5*	−1.1	1.4	1.2	1.4
1717_s_at	BIRC3	−1.0	1.7*	4.1*	2.8*	1.4	4.0*	2.9	5.8*	1.4	−1.1	−1.0	−1.1
37652_at	CABIN1	1.0	1.3	1.5	1.7*	1.1	1.3	1.4	2.0*	−1.0	1.2	−1.1	1.0
35311_at	CREG1	1.1	−1.0	1.2	1.6*	1.3	1.5	1.3	2.0	−1.1	1.1	−1.0	1.0
32168_s_at	DSCR1	1.1	2.1*	4.7*	5.0*	1.5	5.1*	7.4*	4.8*	1.1	1.4	1.4	1.2
36629_at	DSIPI	12.9*	28.0*	21.2*	33.1*	10.1*	42.3*	46.4*	20.4*	18.6*	17.6*	17.3*	5.0*
38555_at	DUSP10	1.6	1.2	2.0*	2.7*	1.5*	1.3	1.9*	1.4	1.4	1.0	1.0	1.2
34721_at	FKBP5	2.4*	4.0*	5.8*	6.6*	1.6*	5.6*	3.6*	4.4*	1.3	1.4	1.7*	2.8*
41431_at	ICK	−1.1	−1.4	1.6	1.4	1.1	−1.1	1.6	−1.9	1.0	−1.0	1.1	1.2
33804_at	PTK2B	1.1	1.8	1.6	2.1*	−1.2	1.1	1.2	4.2*	1.2	−1.3	−1.2	1.1
40631_at	TOB1	1.1	1.2	1.4	1.6*	1.2	1.6*	1.6*	1.5	1.2	1.2	1.1	1.2
31508_at	TXNIP	1.1	1.4	2.8*	2.8*	1.6*	2.3*	2.6*	3.7*	1.0	1.1	1.2	1.2
36601_at	VCL	−1.2	1.3	1.4	1.8	1.1	1.5*	1.3	1.9*	−1.1	1.1	1.1	1.0

Averages of genes induced ≥1. 5X in at least one time point in both glucocorticoid-sensitive cell lines C7-14 and C1-6. Instances at which p-value <0.05 for three treated replicates as compared to their respective time-matched controls and fold change must be ≥1.5 are indicated by *. Note that DSIPI and FKBP5 are induced in resistant C1-15 cells as well as in sensitive clones.