Table 1.
Details of Published Studies on Outcomes of CyberKnife for Vestibular Schwannomas.
| Study | Institution; Study Years | Design; Sample, n | Mean Age, y (Range); Female, % | # of NF2 patients | Number of patients with prior surgical resection and/or radiosurgery (%) | Pretreatment Hearing Levels | Definition of hearing preservation |
|---|---|---|---|---|---|---|---|
| Ishihara (2004)14 | Yamaguchi University, Japan; 1998-2002 | PRO; 40 | 53 (13-80); 53 | 0 | 11 (27.5) underwent prior microsurgery | 14 (I-II) 24 (III-V) |
Gardner-Robertson classification system (GR) I-II is serviceable III-V is nonserviceable |
| Chang (2005)20 | Stanford University School of Medicine, US; 1999-2001 | PRO; 61 | 54 (27-59); 51 | 0 | 8 (13) underwent prior microsurgery | 48 (I-III) 13 (V) |
Gardner-Robertson classification system (GR) I-II is serviceable III-V is nonserviceable |
| Ju (2008)15 | National Yang-Ming University, Taiwan; 2005-2007 | PRO; 21 | 54 (27-79); 52 | 7 | 1 (4.7%) underwent prior microsurgery | 18 (I-IV) 3 (V) |
Gardner-Robertson classification system (GR) I-II is serviceable III-V is nonserviceable |
| Mahadevan (2011)25 | Beth Israel Deaconess Medical Center, US; 2005-2010 | RET; 10 | N/A; N/A | 0 | 0 (0%) | 10 (I-III) | Gardner-Robertson classification system (GR) I-II is serviceable III-V is nonserviceable Preserved objective hearing is I-III |
| Hansasuta (2011)22 | Stanford University School of Medicine, US; 1999-2007 | PRO; 383 | 53a (11-91); 47 | 15 | 41 (11%) underwent prior microsurgery | 287 (I-II) 96 (III-V) |
Gardner-Robertson classification system (GR) I-II is serviceable III-V is nonserviceable |
| Tsai (2013)26 | National Defense Medical Center, Taiwan; 2006-2012 | RET; 117 | 57.3 (24-90); 51 | 0 | 24 (20.5%) | 65 (I-II) 52 (III-IV) |
Gardner-Robertson classification system (GR) I-II is serviceable III-V is nonserviceable |
| Morimoto (2013)27 | Osaka University Hospital, Japan; 1998-2011 | PRO; 25 | 59a (15-81); 60 | 5 | 6 (24%) underwent prior microsurgery | 12 had hearing levels < 50 dB | Only reported dB not GR |
| Karam (2013)21 | MedStar Georgetown University Hospital, US; 2002-2011 | RET; 32 | 58a (31-85); 30 | 0 | 0 (0%) | 14 (I-II) 5 (III-V) Rest unknown |
Gardner-Robertson classification system (GR) I-II is serviceable III-V is nonserviceable |
| Lin (2013)28 | National Taiwan University Hospital, Taiwan; N/A | PRO; 20 | 56 (29-82); 50 | 0 | 0 (0%) | 3 (Class A) 7 (Class B) 10 (Class C) |
AAO-HNS hearing classification system class A, B, C, or D Class A or B is serviceable |
| Vivas (2014)29 | University of Pittsburgh Medical Center, US; 2005-2011 | RET; 58 | 59a (23-86); 56 | 0 | 10 (17%) subtotal resections | 13 (Class A) 15 (Class B) 30 (Class C-D) |
AAO-HNS hearing classification system class A, B, C, or D Class A or B is serviceable |
| Casentini (2015)30 | S. Bortolo City Hospital, Italy; 2003-2011 | PRO; 33 | 63 (28-85); 55 | 2 | 5 (15%) had prior resection or recurrence | 8 (II) 25 (III-V) |
Gardner-Robertson classification system (GR) I-II is serviceable III-V is nonserviceable |
Abbreviations: N/A, not available; NF2, neurofibromatosis type 2; PRO, prospective; RET, retrospective.
a
Median was reported instead of mean.